Add this record wherever your domain’s DNS is managed. That is usually the company you bought your domain from (such as GoDaddy, Namecheap or Squarespace Domains), Cloudflare, or your email provider.
The record creates a new subdomain, in.yourdomain.com, that is used only for your customers’ answers. Leave your existing MX records exactly as they are. They keep your regular email working.
Not sure where your DNS is managed? Contact us and we’ll find out for you.